HumanNet-plus is an enhanced version of the original HumanNet interactome, which integrates over 850,000 cell-type-specific co-expression links inferred from single-cell RNA sequencing (scRNA-seq) data using the scNET framework. This integration significantly improves the interactome's ability to predict disease-associated genes, particularly those linked to specific cell types, by incorporating context-specific interactions that were previously overlooked in traditional, bulk-tissue-derived networks. The integration of these cell-type-specific links provides a more comprehensive and accurate representation of gene interactions, advancing the field of network medicine. Here, we present 100 CGNs integrated with the HumanNet interactome.